Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Recently published papers: Renal support in acute kidney injury is low dose the new high dose? | Available online http content 13 6 1014 Commentary Recently published papers Renal support in acute kidney injury -is low dose the new high dose Yadullah Syed 1 James AP Tomlinson1 and Lui G Forni2 Worthing General Hospital Lyndhurst Road Worthing West Sussex BN11 2DH UK 2Brighton and Sussex Medical Schools University of Sussex Brighton East Sussex BN1 9PX UK Corresponding author Lui G Forni Published 11 December 2009 This article is online at http content 13 6 1014 2009 BioMed Central Ltd Critical Care 2009 13 1014 doi cc8180 Abstract Despite 21st century definitions the management of acute kidney injury remains steadfastly rooted in the 20th century with treatment being principally supportive. Protection from potential causative agents is an essential part of management and to that end protection against contrast-induced nephropathy has received yet more attention. When optimization of volume status haemodynamic parameters electrolyte and acid-base disturbances have failed we turn to renal replacement therapy. The time bought on renal support gives a period for renal recovery but although renal replacement therapy is widely employed many management issues remain unanswered including the timing duration and the dose of treatment. In contrast to respiratory support for acute lung injury for example there is a paucity of large randomized studies addressing these fundamental issues. We describe some recent studies focusing on these issues with the hope that they may lead to better treatment for our patients. The epidemiology and outcome of acute kidney injury AKI continues to be a subject of much interest not least because of the significant mortality morbidity and costs associated with it. To this end the recent study by Thakar and colleagues 1 provides further insights. This is a large retrospective observational study conducted on data collected between 2001 and 2006 in over half a million consecutive ICU .
