Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Bench-to-bedside review: Vaccine protection strategies during pandemic flu outbreaks. | Chua and Chen Critical Care 2010 14 218 http content 14 2 218 CRITICAL CARE REVIEW L_ Bench-to-bedside review Vaccine protection strategies during pandemic flu outbreaks Joel V Chua1 and Wilbur H Chen 2 Abstract Vaccination is the most effective means for the prevention of influenza including pandemic strains. An ideal pandemic influenza vaccine should provide effective protection with the fewest number of doses in the shortest amount of time and among the greatest proportion of the population. The current manufacturing processes required for embryonated chicken-egg-based influenza vaccines are limited in their ability to respond to pandemic situations - these limitations include problems with surge capacity the need for egg-adapted strains the possibility of contamination and the presence of trace egg protein. Several vaccine strategies to circumvent the deficiencies intrinsic to an egg-based influenza vaccine are in various phases of development. These include the use of cell-culture-based growth systems concomitant use of adjuvants whole virus vaccines recombinant protein vaccines plasmid DNA vaccines virus-like particle vaccines and universal flu vaccines. The ever-present threat of influenza Vaccines are the most effective mitigation strategy to protect against disease caused by influenza. The average seasonal influenza epidemic is estimated to cause 36 000 deaths in the United States annually 1 and much more worldwide. The morbidity and mortality during a pandemic is expected to be far greater however as seen in the 1918 Spanish flu wherein between 40 and 50 million people died 2 3 . The current novel 2009 H1N1 virus arose and circulated rapidly such that a global pandemic was declared within 2 months of initial recognition. Thankfully this Correspondence wchen@ 2Center for Vaccine Development 685 W Baltimore Street HSF1 Room 480 Baltimore MD 21201 USA Full list of author information is available at the end of the .
