Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Metabolic cycle, cell cycle, and the finishing kick to Start. | Opinion Metabolic cycle cell cycle and the finishing kick to Start Bruce Futcher Address Department of Molecular Genetics and Microbiology Stony Brook University Stony Brook NY 11794 USA. Email bfutcher@ Published 26 April 2006 Genome Biology 2006 7 107 doi gb-2006-7-4-107 The electronic version of this article is the complete one and can be found online at http 2006 7 4 107 2006 BioMed Central Ltd Abstract Slowly growing budding yeast store carbohydrate then liquidate it in late G1 phase of the cell cycle superimposing a metabolic cycle on the cell cycle. This metabolic cycle may separate biochemically incompatible processes. Alternatively it may provide a burst of energy and material for commitment to the cell cycle. Stored carbohydrate could explain the size requirement for cells passing the Start point. Yeast like my children are at their most vibrant in high concentrations of sugar. The budding yeast Saccharomyces cerevisiae extracts just 2 moles of ATP per mole of glucose via fermentation that is glycolysis to pyruvate then reduction of the pyruvate to ethanol but it grows rapidly with a doubling time of about one and a half hours. In low concentrations of glucose or in non-fermentable carbon sources yeast grow via oxidative respiration extracting more than 30 moles of ATP per mole of glucose - but now their doubling time increases to 3 hours or longer. Yeast growing oxidatively in limited glucose use this glucose in three major ways. First of course they use it as an energy source glucose flows through glycolysis to generate ATP NADH and pyruvate and the pyruvate flows through the tricarboxylic acid TCA cycle and oxidative phosphorylation to generate even more ATP. Second they use glucose as a raw material for building the cell wall. Third another large portion of the glucose is stored some in the polysaccharide glycogen and some in the disaccharide trehalose. So even though these respiring cells are in some sense .
