Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The association of Streptococcus bovis/gallolyticus with colorectal tumors: The nature and the underlying mechanisms of its etiological role | Abdulamir et al. Journal of Experimental Clinical Cancer Research 2011 30 11 http content 30 1 11 Journal of Experimental Clinical Cancer Research REVIEW Open Access The association of Streptococcus bovis gallolyticus with colorectal tumors The nature and the underlying mechanisms of its etiological role Ahmed S Abdulamir Rand R Hafidh Fatimah Abu Bakar Abstract Streptococcus bovis S. bovis bacteria are associated with colorectal cancer and adenoma. S. bovis is currently named S. gallolyticus. 25 to 80 of patients with S. bovis gallolyticus bacteremia have concomitant colorectal tumors. Colonic neoplasia may arise years after the presentation of bacteremia or infectious endocarditis of S. bovis gallolyticus. The presence of S. bovis gallolyticus bacteremia and or endocarditis is also related to the presence of villous or tubular-villous adenomas in the large intestine. In addition serological relationship of S. gallolyticus with colorectal tumors and direct colonization of S. gallolyticus in tissues of colorectal tumors were found. However this association is still under controversy and has long been underestimated. Moreover the etiological versus non-etiological nature of this associationis not settled yet. Therefore by covering the most of up to date studies this review attempts to clarify the nature and the core of S. bovis gallolyicus association with colorectal tumors and analyze the possible underlying mechanisms. Introduction statement of the problem One of the bacterial agents that has been found to be regularly associated with colorectal cancer is Streptococcus bovis S. bovis . S. bovis has been shown to have important impact on health since 25 to 80 of patients with S. bovis bacteremia have colorectal tumors and the incidence of association of colonic neoplasia with S. bovis endocarditis has been shown to be 18 to 62 1-7 . It was shown that 94 of S. bovis bacteremia associated with colorectal cancer was in fact S. bovis biotype I while only
