In addition, this γ-lactam heterocyclic ring also exists in synthetic medicinal compounds. In this manuscript, multi-component reactions (MCRs) were applied to synthesize three 1,5- disubstituted-4-ethoxycarbonyl-3-hydroxy-3-pyrroline-2-ones containing nitro group from aromatic aldehydes, 4-nitroaniline and sodium diethyl oxalacetate in absolute ethanol. |