The MeOH extract of Nam ginseng (roots and rhizomes of Dracaena angustifolia) afforded two new furostanol saponins, named namonins E and F (1 and 2), along with another four known steroidal saponins (3 - 6). Their structures were determined on basis of spectral analyses and chemical methods. All compounds were tested for their antiproliferative activity against murine colon 26-L5 carcinoma, human HT-1080 fibrosar- coma and B-16 BL6 melanoma cells. Compounds 10, 11 and 14 showed potent antiprolife- rative activity against HT-1080 fibrosarcoma cells, having IC50 values of µM, µM and µM, respectively, comparable to that of doxorubicin.
