Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Arginine vasopressin versus norepinephrine: will the stronger one win the race? | Available online http content 10 3 144 Commentary Arginine vasopressin versus norepinephrine will the stronger one win the race Christian Ertmer Hans-Georg Bone and Martin Westphal Department of Anesthesiology and Intensive Care University of Muenster Muenster Germany Corresponding author Martin Westphal Published 25 May 2006 This article is online at http eontent 10 3 144 2006 BioMed Central Ltd Critical Care 2006 10 144 doi cc4942 See related research by Friesenecker et al. http content 10 3 R75 Abstract In the current issue of Critical Care Friesenecker and colleagues present a well-designed comparative study on the microvascular effects of arginine vasopressin AVP and norepinephrine NE in a physiological unanesthetized hamster model. The authors clearly demonstrate that AVP but not NE has marked vasoconstrictive effects on large arterioles whereas the impact on small arterioles is comparable for both vasopressors. However it remains unclear if these results per se reflect a stronger vasopressive potential of AVP versus NE as macrohemodynamic variables were not different between study groups. Since the authors did not investigate the effects of AVP and NE in vasodilatory shock states the microcirculatory response in sepsis or systemic inflammatory response syndrome remains inconclusive. The same authors previously reported that AVP infusion in patients suffering from vasodilatory shock carries the risk for ischemic skin lesions. This in turn raises the question whether the quality of vasopressors should be judged by their potency. In the current issue of Critical Care Friesenecker and colleagues 1 present a well-designed comparative study on the microvascular effects of arginine vasopressin AVP and norepinephrine NE in awake hamsters under physiological conditions. The authors used the dorsal skinfold window chamber technique to measure vascular diameter crosssectional area and blood flow of .
