Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: The genetics of chronic obstructive pulmonary disease. | Respiratory Research BioMed Central Open Access The genetics of chronic obstructive pulmonary disease Alice M Wood1 and Robert A Stockley 2 Address Department of Medical Sciences University of Birmingham Birmingham UK and 2Lung Investigation Unit University Hospitals Birmingham Birmingham B15 2TH UK Email Alice M Wood - Robert A Stockley - Corresponding author Published 20 October 2006 Received 22 September 2006 Respiratory Research 2006 7 130 doi 1465-9921-7-130 Accepted 20 October 2006 This article is available from http content 7 1 130 2006 Wood and Stockley licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Chronic obstructive pulmonary disease COPD is a heterogeneous disease caused by the interaction of genetic susceptibility and environmental influences. There is increasing evidence that genes link to disease pathogenesis and heterogeneity by causing variation in protease anti-protease systems defence against oxidative stress and inflammation. The main methods of genomic research for complex disease traits are described together with the genes implicated in COPD thus far their roles in disease causation and the future for this area of investigation. Background Chronic obstructive pulmonary disease COPD is characterised by airflow limitation that is not fully reversible which usually progresses together with an abnormal inflammatory response to noxious particles or gases 1 . Patients may have chronic bronchitis 2 emphysema 3 small airways disease or a combination of these with or without systemic manifestations of the disease 4 . This results in great .
