Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Kinetics of plasmatic cytokines and cystatin C during and after hem odialysis in septic shock-related acute renal failure. | Mayeur et al. Critical Care 2010 14 R115 http content 14 3 R115 RESEARCH Open Access Kinetics of plasmatic cytokines and cystatin C during and after hemodialysis in septic shock-related acute renal failure Nicolas Mayeur 1 Lionel Rostaing2 Marie B Nogier2 Acil Jaafar3 Olivier Cointault2 Nassim Kamar2 Jean M Conil1 Olivier Fourcade1 and Laurence Lavayssiere2 Abstract Introduction Cystatin C could be a relevant residual glomerular filtration rate marker during hemodialysis HD and a high cytokine plasma p rate is associated with an increase in mortality during sepsis. To the best of our knowledge cytokines and cystatin C kinetics during and after HD during sepsis have never been studied. In this study we described p cytokines and cystatin C variations during and after hemodialysis in septic-shock patients with acute kidney injury AKI . Methods Ten patients from two tertiary ICUs with septic shock-related AKI according to RIFLE class F were studied. In this prospective observational study blood samples were collected at the start after 1 hour 2 hours and at the end of HD with a polymethymethacrylate PMMA hemodialyzer D0 D1 D2 and endD and 30 60 90 120 and 180 min after HD postD1 postD2 and postD3 . We measured p interleukins IL -6 IL-8 IL-10 cystatin C and albumin. Results are expressed as variations from D0 mean SD . Results During HD p IL-6 did not vary significantly whereas p IL-8 and p IL-10 reductions by D1 were and 26 respectively P as compared with D0 . At postD3 p IL-8 and p IL-10 returned to their initial values. p Cystatin C was significantly reduced from D1 to postD1 with a maximal reduction of 30 on D2 P . Norepinephrine infusion rate decreased from D0 to postD3 to pg kg min P . Conclusions HD allows a transient and selective decrease in p cytokines which are known as being correlated with mortality during septic shock. Because of a significant decrease in p cystatin C .
