Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài:" Retroviral activation of the mir-106a microRNA cistron in T lymphoma. | Retrovirology BioMed Central Short report Open Access Retroviral activation of the mir-l06a microRNA cistron in T lymphoma Amy M Lum1 Bruce B Wang1 Lauri Li1 Namitha Channa1 Gabor Bartha2 and Matthias Wabl 3 Address 1Picobella . 863 Mitten Road Suite 101 Burlingame CA 94010 USA 2Synergenics . 863 Mitten Road Suite 101 Burlingame CA 94010 USA and 3Department of Microbiology and Immunology University of California San Francisco CA 94143-0414 USA Email Amy M Lum - amy@ Bruce B Wang - bruce@ Lauri Li - lauri@ Namitha Channa - namitha@ Gabor Bartha - gabor@ Matthias Wabl - mutator@ Corresponding author Published 25 January 2007 Received 12 December 2006 Accepted 25 January 2007 Retrovirology 2007 4 5 doi 86 1742-4690-4-5 This article is available from http content 4 1 5 2007 Lum et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Retroviral insertion into a host genome is a powerful tool not only for the discovery of cancer genes but also for the discovery of potential oncogenic noncoding RNAs. In a large-scale mouse T lymphocyte tumor screen we found a high density of integrations upstream of the mir-106a microRNA cistron. In tumors containing an integration the primary transcript encoding the mir-l06a cistron was overexpressed five to 20-fold compared with that of control tumors concomitantly the mature mir-106a and mir-363 microRNAs were highly overexpressed as well. These findings suggest the mir-l06a cistron plays an important role in T cell tumorigenesis. Findings Retroviral insertions into the genome of a host can induce tumor formation by altering gene expression or function. Integration of a .
