The association of obesity with colorectal cancer (CRC) may vary depending on metabolic status. The individuals with metabolic abnormality, although at a normal weight, have an increased risk for CRC. Moreover, obesity is associated with CRC irrespective of metabolic status. | Goodarzi et al. BMC Cancer 2022 22 89 https s12885-021-09149-w RESEARCH Open Access Metabolic phenotypes and risk of colorectal cancer a systematic review and meta-analysis of cohort studies Golnoosh Goodarzi1 Hadis Mozaffari2 Tahereh Raeisi3 Fatemeh Mehravar4 Bahman Razi5 Maryam Lafzi Ghazi6 Nazila Garousi7 Shahab Alizadeh8 and Parisa Janmohammadi8 Abstract Background The association of obesity with colorectal cancer CRC may vary depending on metabolic status. Objective This meta-analysis aimed to investigate the combined impacts of obesity and metabolic status on CRC risk. Methods The Scopus PubMed and web of sciences databases were systematically searched up to Jun 2021 to find all eligible publications examining CRC risk in individuals with metabolically unhealthy normal-weight MUHNW metabolically healthy obesity MHO and metabolically unhealthy obesity MUHO phenotypes. Results A total of 7 cohort studies with a total of 759 066 participants were included in this meta-analysis. Compared with healthy normal-weight people MUHNW MHO and MUHO individuals indicated an increased risk for CRC with a pooled odds ratio of 95 CI in MUHNW 95 CI in MHO and 95 CI in MUHO subjects. When analyses were stratified based on gender associations remained significant for males. However the elevated risk of CRC associated with MHO and MUHO was not significant in female participants. Conclusions The individuals with metabolic abnormality although at a normal weight have an increased risk for CRC. Moreover obesity is associated with CRC irrespective of metabolic status. Keywords Obesity Colorectal cancer Phenotypes Introduction pattern increases the risk of CRC. Obesity which is Colorectal cancer CRC is the third most common closely associated with the Western dietary pattern is cancer in men and the second one in women over also a risk factor for colorectal cancer 3 4 . The major- million new cases of CRC were recorded
