Bài viết Đánh giá tác dụng bảo vệ gan của cao chiết nước phần gỗ loài bàn tay ma đỏ (heliciopsis lobata merr.) trồng tại Bắc Kạn tập trung vào đánh giá tác dụng bảo vệ gan và độc tính cấp của cao chiết nước thân gỗ dược liệu Bàn tay ma đỏ. | VNU Journal of Science Medical and Pharmaceutical Sciences Vol. 38 No. 4 2022 86-95 Original Article Evaluation of the Hepatoprotective Activity of the Wood of Heliciopsis lobata Merr. Sleumer Bui Van Trung1 Nguyen Thu Hang2 Duong Hong Anh3 Pham Hung Viet3 1 National Institute of Drug Quality Control 48 Hai Ba Trung Hoan Kiem Hanoi Vietnam 2 Vinh Medical University 116 Nguyen Phong Sac Vinh city Nghe An Vietnam 3 VNU University of Science 334 Nguyen Trai Thanh Xuan Hanoi Vietnam Received 26 October 2022 Revised 23 November 2022 Accepted 25 November 2022 Abstract Heliciopsis lobata Merr. Sleumer is a popular herbal material in the North-West territories of Vietnam. The wood of this plant is still used for the treatment of some liver diseases although there is no scientific evidence for evaluating these activities and the safety of this herbal material. Our study focused on accessing acute toxicity and hepatoprotective activity of water extract from the wood of Heliciopsis lobata. Among experimental groups of mice induced by high dosage of paracetamol mice were treated with extract at dosages of g kg g kg and g kg could be against liver damage with different levels. Water extract at dosages of g kg and g kg could maintain the original situation of livers significantly reduced the increase of ALT and AST enzymes at levels of about 80 and 87 respectively significantly reduced 70 the increase of AST and against most of the peroxidation process in liver tissue. A dosage of g kg expressed lower hepatoprotective activities in comparison with the former dosages and which may increase liver toxicity when used with high dosages of paracetamol. The highest experimental dosage at g kg did not show acute toxicity by independent oral administration. It could be concluded that water extract of the wood of Heliciopsis lobata exposed hepatoprotective ability with dosage from g kg to g kg equivalent to dosages from 60 g to 120 g for .
