Nghiên cứu tác dụng ức chế tế bào ung thư của vỏ quả Xuyên tiêu (Zanthoxylum simulans Hance.)

Cây Xuyên tiêu (Zanthoxylum simulans Hance.) được biết đến trong dân gian là một loại gia vị ấm nóng, cay và thường dùng chữa các chứng bệnh do lạnh gây ra trong cơ thể. Bài viết nghiên cứu tác dụng ức chế tế bào ung thư của vỏ quả Xuyên tiêu (Zanthoxylum simulans Hance.). | VNU Journal of Science Medical and Pharmaceutical Sciences Vol. 39 No. 2 2023 53-58 Original Article Cytotoxicity Effects of Zanthoxylum simulans Hance. Fruit Bark Extract Dang Thuy Tien1 Nguyen Thi Thuy1 Vu Manh Ha2 Bui Thanh Tung1 1 VNU University of Medicine and Pharmacy 144 Xuan Thuy Cau Giay Hanoi Vietnam 2 Phenikaa University Nguyen Trac Yen Nghia Ha Dong Hanoi Vietnam Received 10 March 2023 Revised 29 April 2023 Accepted 10 June 2023 Abstract Zanthoxylum simulans Hance. is known in folklore as a spicy herb commonly used to treat cold-induced diseases in the body. In this study we evaluated the cytotoxic effects of Zanthoxylum simulans fruit bark extract. Samples of Zanthoxylum simulans were extracted with 70 ethanol and subsequently fractionated with n-Hexane ethyl acetate EtOAc and n-butanol n-BuOH solvents. To evaluate the cytotoxic effect we performed SRB Sulforhodamine B assay on the three cell lines human liver HepG2 lung SK-LU-1 and cervical carcinoma Hela. The results showed that the EtOH total extract had the strongest cytotoxicity effects on liver cancer cells with an IC50 of g mL but showed no toxicity to SK-LU-1 lung cancer or Hela cervical cancer cells. The results of cytotoxic effects on HepG2 liver cancer cells of these fractions showed that the n-Hexane and EtOAc fractions exhibited activity with IC50 values of and µg mL respectively while the n-BuOH and H2O fractions showed no activity. Our results showed that Zanthoxylum simulans fruit bark extract has a strong cytotoxicity effect on liver cancer cells. Keywords Zanthoxylum simulans Hance. cytotoxicity SRB liver cancer cells. _ Corresponding author. E-mail address tungasia82@ https 2588-1132 53 54 D. T. Tien et al. VNU Journal of Science Medical and Pharmaceutical Sciences Vol. 39 No. 2 2023 53-58 Nghiên cứu tác dụng ức chế tế bào ung thư của vỏ quả Xuyên tiêu Zanthoxylum simulans Hance. Đặng Thủy Tiên1 Nguyễn Thị Thúy1 .