Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Current status of haploidentical stem cell transplantation for leukemia | Journal of Hematology Oncology BioMed Central Open Access Current status of haploidentical stem cell transplantation for leukemia Xiao-jun Huang Address Institute of Hematology People s Hospital Peking University No 11 Xi Zhi Men South Street Beijing 10044 PR China Email Xiao-jun Huang - xjhrm@ Published 31 December 2008 Received 18 October 2008 Journal of Hematology Oncology 2008 1 27 doi 1756-8722-1-27 Accepted 31 December 2008 This article is available from http content 1 1 27 2008 Huang licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Haploidentical hematopoietic stem cell transplantation has made tremendous progress over the past 20 years and has become a feasible option for leukemia patients without a HLA identical sibling donor. The early complications of severe graft-versus-host disease GVHD graft failure and delayed engraftment as well as disease recurrence have limited the use of this approach. Newer strategies have been applied and overcome some of the problems including the use of T-cell depleted graft mega dose of stem cells intensive post-transplant immunosuppression and manipulation of the graft. These have decreased the transplant related mortality and GVHD associated with haploidentical transplantation however the major problems of disease relapse and infection which related to late immune reconstitution limit the development of haploidentical HSCT. Future challenges remain in improving post-transplant immune reconstitution and finding the best approach to reduce the incidence and severity of GVHD while preserving graft-versus-leukemia effect to prevent the recurrence of underlying malignancy. Background Hematopoietic stem cell transplantation is a good and .
