Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Human CNS cultures exposed to HIV-1 gp120 reproduce dendritic injuries of HIV-1-associated dementia Sam Iskander1, Kimberley A Walsh1 and Robert R | Journal of Neuroinflammation BioMed Central Research Open Access Human CNS cultures exposed to HIV-I gp120 reproduce dendritic injuries of HIV-1-associated dementia Sam Iskander1 Kimberley A Walsh1 and Robert R Hammond 1 2 Address Department of Pathology London Health Sciences Centre University of Western Ontario London ON Canada and 2Department of Clinical Neurological Sciences London Health Sciences Centre University of Western Ontario London ON Canada Email Sam Iskander - Kimberley A Walsh - kim_walsh41@ Robert R Hammond - rhammond@ Corresponding author Published 27 May 2004 Received 08 April 2004 Accepted 27 May 2004 Journal of Neuroinflammation 2004 1 7 This article is available from http content 1 1 7 2004 Iskander et al licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract HIV-1-associated dementia remains a common subacute to chronic central nervous system degeneration in adult and pediatric HIV-1 infected populations. A number of viral and host factors have been implicated including the HIV-1 120 kDa envelope glycoprotein gp120 . In human postmortem studies using confocal scanning laser microscopy for microtubule-associated protein 2 and synaptophysin neuronal dendritic pathology correlated with dementia. In the present study primary human CNS cultures exposed to HIV-1 gp1 20 at 4 weeks in vitro suffered gliosis and dendritic damage analogous to that described in association with HIV-1-associated dementia. Introduction HIV-1-associated dementia HAD is a late subacute to chronic dementia characterized by a progressive and severe decline in cognitive and motor function. HAD remains a major debilitating consequence of HIV-1 infection. It is an independent risk factor for death from AIDS and the most common form
