Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Leader (L) and L* proteins of Theiler's murine encephalomyelitis virus (TMEV) and their regulation of the virus' biological activities | Journal of Neuroinflammation BioMed Central Open Access Review Leader L and L proteins of Theiler s murine encephalomyelitis virus TMEV and their regulation of the virus biological activities Masumi Takano-Maruyama Yoshiro Ohara Kunihiko Asakura and Takako Okuwa Address Department of Microbiology Kanazawa Medical University Uchinada Ishikawa 920-0293 Japan Email Masumi Takano-Maruyama - maru0812@ Yoshiro Ohara - ohara@ Kunihiko Asakura - kasakura@ Takako Okuwa - tokuwa@ Corresponding author Published 16 August 2006 Received 05 January 2006 Journal of Neuroinflammation 2006 3 19 doi l742-2094-3-l9 Accepted 16 August 2006 This article is available from http content 3 l l9 2006 Takano-Maruyama et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Theiler s murine encephalomyelitis virus TMEV is divided into two subgroups on the basis of their different biological activities. GDVII subgroup strains produce fatal poliomyelitis in mice without virus persistence or demyelination. In contrast TO subgroup strains induce demyelinating disease with virus persistence in the spinal cords of weanling mice. Two proteins whose open reading frames are located in the N-terminus of the polyprotein recently have been reported to be important for TMEV biological activities. One is leader L protein and is processed from the most N-terminus of the polyprotein its function is still unknown. Although the homology of capsid proteins between DA a representative strain of TO subgroup and GDVII strains is over 94 at the amino acid level that of L shows only 85 .
