Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Enhancing the efficacy of cisplatin in ovarian cancer treatment – could arsenic have a role | Journal of Ovarian Research BioMed Central Open Access Review Enhancing the efficacy of cisplatin in ovarian cancer treatment -could arsenic have a role C William Helm 1 and J Christopher States2 Address Department of Obstetrics Gynecology Women s Health University of Louisville School of Medicine Louisville KY 40292 USA and 2Department of Pharmacology Toxicology University of Louisville School of Medicine Louisville KY 40292 USA Email C William Helm - cwhelm@ J Christopher States - jcstatoi @ Corresponding author Published 14 January 2009 Received 8 October 2008 Journal of Ovarian Research 2009 2 2 doi l757-22l5-2-2 Accepted I4 January 2009 This article is available from http content 2 l 2 2009 Helm and States licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Ovarian cancer affects more than 200 000 women each year around the world. Most women are not diagnosed until the disease has already metastasized from the ovaries with a resultant poor prognosis. Ovarian cancer is associated with an overall 5 year survival of little more than 50 . The mainstay of front-line therapy is cytoreductive surgery followed by chemotherapy. Traditionally this has been by the intravenous route only but there is more interest in the delivery of intraperitoneal chemotherapy utilizing the pharmaco-therapeutic advantage of the peritoneal barrier. Despite three large randomized clinical trials comparing intravenous with intraperitoneal chemotherapy showing improved outcomes for those receiving at least part of their chemotherapy by the intraperitoneal route. Cisplatin has been the most active drug for the treatment of ovarian cancer for the last 4 decades and the prognosis for
