Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Changes in androgens and insulin sensitivity indexes throughout pregnancy in women with polycystic ovary syndrome (PCOS): relationships with adverse outcomes | Falbo et al. Journal of Ovarian Research 2010 3 23 http content 3 1 23 RESEARCH JOURNAL OF OVARIAN RESEARCH Open Access Changes in androgens and insulin sensitivity indexes throughout pregnancy in women with polycystic ovary syndrome PCOS relationships with adverse outcomes 1 1 1 2 2 1 3 Angela Falbo Morena Rocca Tiziana Russo Antonietta D Ettore Achille Tolino Fulvio Zullo Francesco Orio Stefano Palomba1 Abstract Background Given the high rate of pregnancy and perinatal complications recently observed in patients with polycystic ovary syndrome PCOS and the lack of data on the serum variations in androgens and insulin sensitivity indexes in pregnant women with PCOS the current study was aimed to assess these changes and their potential effect on pregnancy outcomes in a population of women with PCOS. Methods Forty-five pregnant patients with ovulatory PCOS PCOS group and other 42 healthy pregnant women control group were studied assaying serum androgen levels and insulin sensitivity indexes throughout pregnancy serially and recording obstetrical outcomes. Results Serum androgen levels and insulin resistance indexes were significantly p higher in PCOS than in control group at study entry these differences were sustained throughout pregnancy and their changes resulted significantly p different between PCOS and control group. In PCOS patients women who had a complicated pregnancy showed serum androgen levels and insulin sensitivity indexes significantly p worse in comparison to subjects without any pregnancy and or neonatal complications. Conclusions PCOS patients have impaired changes in serum androgen levels and insulin sensitivity indexes during pregnancy. These alterations could be implicated in the pregnancy and neonatal complications frequently observed in women affected by PCOS. Background Polycystic ovary syndrome PCOS is a heterogeneous disorder characterized by biochemical alteration . hyperandrogenism and insulin .
