Bài viết trình bày tổng quan về cấu trúc hóa học và tác dụng sinh học của các hợp chất phenolic trong kim ngân hoa. Kim ngân hoa (KNH) được sử dụng rộng rãi làm thuốc tại Việt Nam là nụ hoa có lẫn một số hoa đã phơi sấy khô của cây kim ngân (Lonicera japonica Thunb.) và một số loài khác cùng chi như Lonicera dasystyla Rehd., Lonicera confusa DC., Lonicera cambodiana Pierre ex Danguy , họ Kim ngân (Caprifoliaceae). | VNU Journal of Science Medical and Pharmaceutical Sciences Vol. 38 No. 4 2022 13-32 Review Article Flos Lonicerae A Review of Chemical Structures and Biological Activities of Phenolic Derivatives Pham Quoc Tuan1 Tran Thi Van Anh1 Nguyen Thanh Hai2 Ha Quang Loi1 Dao Viet Hung1 Ha Thanh Hoa1 Nguyen Thi Minh Diep1 Ngo Thi Xuan Thinh1 1 Phu Tho College of Medicine and Pharmacy 2201 Hung Vương Gia Cam Viet Tri Phu Tho Vietnam 2 VNU School of Medicine and Pharmacy 144 Xuan Thuy Cau Giay Hanoi Vietnam Received 16 August 2022 Revised 27 August 2022 Accepted 28 August 2022 Abstract Flos Lonicerae a widely used Vietnamese medicinal material is the dried buds or flowers of Lonicera japonica Thunb. and several other species of genus Lonicera such as Lonicera dasystyla Rehd. Lonicera confusa DC. Lonicera cambodiana Pierre ex Danguy belonging to the family Caprifoliaceae. This material has been used for a long time in traditional medicine for clearing heat removing toxins and dispersing wind heat. According to a variety of recent phytochemistry and biological studies that we systematically summarized Flos Lonicerae contains 129 phenolic derivatives including 48 flavonoids 13 lignans and neolignans 55 phenolic acid derivatives and 13 other phenolic compounds. These phenolic compounds have remarkable biological effects such as antibacterial antiviral antioxidant anti-inflammatory anti-cancer hepatoprotective anti- endotoxin anti-allergic anti-diabetic cardioprotective anti-allergic activities etc. In particular chlorogenic acid a prominent component with significant biological activities is utilized as a marker compound to evaluate the quality of Flos Lonicerae in the Vietnamese and Chinese Pharmacopoeia. Keywords Flos Lonicerae Phenolic derivatives Chemical structures Biological activities Chlorogenic acid. _ Corresponding author. E-mail address phamquoctuan@ https 2588-1132 13 14 P. Q. Tuan et al. VNU Journal of Science Medical and
