Cấu trúc một số flavonoid phân lập từ loài BanHooker (Hypericum hookerianumWight & Arn.)

Cây ban Hooker (H. hookerianum) được tìm thấy ở nhiều quốc gia Châu Á. Ở Việt Nam, ban Hooker mọc hoang nhiều ở vùng núi Sa Pa, tỉnh Lào Cai. Lá cây ban Hooker được người dân sử dụng để chữa đau mắt cho gia súc. Bài viết trình bày việc phân lập và xác định cấu trúc hóa học của các hợp chất flavonoid từ cây ban Hooker. | Nghiên cứu Dược amp Thông tin thuốc 2022 Tập 13 Số 6 trang 2-9 BÀI NGHIÊN CỨU Chemical structures of flavonoids from Hypericum hookerianum Wight amp Arn Vu Duy Hong1 2 Vu Van Tuan3 Phuong Thien Thuong4 Nguyen Minh Khoi2 Nguyen Manh Tuyen5 1 National Institute of Hematology and Blood Transfusion 2 National Institute of Medicinal Materials 3 Faculty of Pharmacy Phenikaa University 4 Vietnam - Korea Institute of Science and Technology 5 Faculty of Pharmacognosy and Traditional Medicine Hanoi University of Pharmacy Corresponding author 0973229194 tuyennm@ ABSTRACT Background Hypericum hookerianum is widely distributed in Asian countries. In Vietnam this species is found abundantly in the northern mountains Sapa district Lao Cai province . The leaves of H. hookerianum have been applied in Vietnamese Traditional Medicine to treat eye pain for cattle. To date there have not been reported study on avonoids of H. hookerianum. Aim The aim of this study was to isolate and determine the chemical structures of avonoids from H. hookerianum. Method The compounds were isolated and puri ed by column chromatography. The chemical structures of avonoids were elucidated by the analyses of Mass spectrometry MS and Nuclear magnetic resonance NMR spectroscopy and comparison with those reported in the literature. Results Eight avonoids 1 8 was isolated from the methanol extract of the aerial parts of Hypericum hookerianum collected in Sa Pa Lao Cai Vietnam . These isolates were identi ed as kaempferol 1 hyperoside 2 astilbin 3 engeletin 4 isorhamnetin-3-O-β-D- glucopyranoside 5 rutin 6 nicoti orin 7 and 3 8 -biapigenin 8 . All avonoids have been rstly isolated from H. hookerianum. This is the rst report on the occurrence of isorhamnetin- 3-O-β-D-glucopyranoside 5 in the genus Hypericum. Conclusions The results provide new information on the phytochemical pro le of genus Hypericum generally and of species H. hookerianum particularly. Keywords Hypericum hookerianum avonoids .