Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Incidence and clinicopathologic behavior of uterine cervical carcinoma in renal transplant recipients | Park et al. World Journal of Surgical Oncology 2011 9 72 http content 9 1 72 7 WORLD JOURNAL OF SURGICAL ONCOLOGY RESEARCH Open Access Incidence and clinicopathologic behavior of uterine cervical carcinoma in renal transplant recipients 121 1 3 Sung Taek Park Min Jong Song Jong Sup Park Soo Young Hur and Chung Won Lee Abstract Background Renal allograft recipients are reported to have a higher incidence of malignancy than the general population. This single hospital-based study examined the incidence and clinicopathologic behavior of uterine cervical carcinoma in renal transplant recipients. Methods Among 453 women receiving renal transplantation from January 1990 to December 2008 5 patients were diagnosed with cervical carcinoma. Medical records of these 5 patients were retrospectively reviewed and clinicopathologic data were collected and analyzed. Results The incidence of cervical carcinoma in renal transplant recipients was out of 100 000 per year which is times higher than in the general Korean population. The mean interval between the time of renal transplantation and the time of cervical carcinoma diagnosis was months. After a median follow-up of months there was no recurrence of the disease or death. In 4 patients who were positive from human papillomavirus in situ hybridization HPV ISH high or probably high risk HPV DNA was detected in all. Punctate staining of HPV ISH was detected in 3 out of 4 patients. Conclusions Higher incidence of cervical carcinoma is expected in renal transplant recipients so appropriate surveillance is needed to ensure early detection and treatment of cervical carcinoma. Keywords Cervical carcinoma Renal transplantation Human papillomavirus Clinicopathologic behavior Background Recent advancements in immunosuppressive therapy have reduced cases of acute rejection and improved the long-term survival rate of grafts in organ transplant patients. Long-term use of immunosuppressants has likewise .
