Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: " Ramipril mitigates radiation-induced impairment of neurogenesis in the rat dentate gyrus. | Jenrow et al. Radiation Oncology 2010 5 6 http content 5 1 6 RADIATION ONCOLOGY RESEARCH Open Access Ramipril mitigates radiation-induced impairment of neurogenesis in the rat dentate gyrus Kenneth A Jenrow1 Stephen L Brown2 Jianguo Liu2 Andrew Kolozsvary2 Karen Lapanowski2 Jae Ho Kim2 Abstract Background Sublethal doses of whole brain irradiation WBI are commonly administered therapeutically and frequently result in late delayed radiation injuries manifesting as severe and irreversible cognitive impairment. Neural progenitors within the subgranular zone SGZ of the dentate gyrus are among the most radiosensitive cell types in the adult brain and are known to participate in hippocampal plasticity and normal cognitive function. These progenitors and the specialized SZG microenvironment required for neuronal differentiation are the source of neurogenic potential in the adult dentate gyrus and provide a continuous supply of immature neurons which may then migrate into the adjacent granule cell layer to become mature granule cell neurons. The extreme radiosensitivity of these progenitors and the SGZ microenvironment suggests the hippocampus as a prime target for radiation-induced cognitive impairment. The brain renin-angiotensin system RAS has previously been implicated as a potent modulator of neurogenesis within the SGZ and selective RAS inhibitors have been implicated as mitigators of radiation brain injury. Here we investigate the angiotensin converting enzyme ACE inhibitor ramipril as a mitigator of radiation injury in this context. Methods Adult male Fisher 344 rats received WBI at doses of 10 Gy and 15 Gy. Ramipril was administered beginning 24 hours post-WBI and maintained continuously for 12 weeks. Results Ramipril produced small but significant reductions in the deleterious effects of radiation on progenitor proliferation and neuronal differentiation in the rat dentate gyrus following 10 Gy-WBI but was not effective following 15 Gy-WBI. .
