Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Mechanical tuning of molecular machines for nucleotide recognition at the air-water interface | Mori et al. Nanoscale Research Letters 2011 6 304 http content 6 1 304 o Nanoscale Research Letters a SpringerOpen Journal NANO EXPRESS Open Access Mechanical tuning of molecular machines for nucleotide recognition at the air-water interface 1 1 1 2 3 Taizo Mori Ken Okamoto Hiroshi Endo Keita Sakakibara Jonathan P Hill Satoshi Shinoda Miki Matsukura3 Hiroshi Tsukube2 3 Yasumasa Suzuki4 Yasumasa Kanekiyo4 and Katsuhiko Ariga1 2 Abstract Molecular machines embedded in a Langmuir monolayer at the air-water interface can be operated by application of lateral pressure. As part of the challenge associated with versatile sensing of biologically important substances we here demonstrate discrimination of nucleotides by applying a cholesterol-armed-triazacyclononane host molecule. This molecular machine can discriminate ribonucleotides based on a twofold to tenfold difference in binding constants under optimized conditions including accompanying ions in the subphase and lateral surface pressures of its Langmuir monolayer. The concept of mechanical tuning of the host structure for optimization of molecular recognition should become a novel methodology in bio-related nanotechnology as an alternative to traditional strategies based on increasingly complex and inconvenient molecular design strategies. Introduction Supramolecular structures constructed through bottom-up processes play crucial roles in nanoscience and nanotechnology 1 2 . In particular those structures can be applied in bio-related nanotechnologies such as drug discrimination. Molecular assemblies immobilized at the air-water interface are appropriate media for incorporation of the sensing and diagnostic modules of aqueous biological molecules since they provide great opportunities for molecular recognition of water-soluble guests by designer hosts in an insoluble floating monolayer 3 . Enhanced binding efficiencies of host-guest recognition at the air-water interface are in accord
