Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Hemolysis and hyperhomocysteinemia caused by cobalamin deficiency: three case reports and review of the literature | BioMed Central Journal of Hematology Oncology Open Access Case report Hemolysis and hyperhomocysteinemia caused by cobalamin deficiency three case reports and review of the literature Utkarsh Acharya1 Jen-Tzer Gau 1 William Horvath2 Paolo Ventura3 Chung-Tsen Hsueh4 and Wayne Carlsen1 Address Department of Geriatric Medicine Ohio University College of Osteopathic Medicine Athens OH USA 2Department of Internal Medicine University of Toledo College of Medicine Toledo OH USA 3Department of Medicines and Medical Specialties University of Modena and Reggio Emilia Modena Italy and 4Division of Hematology-Oncology Department of Internal Medicine Loma Linda University Loma Linda CA USA Email Utkarsh Acharya - . 1@ Jen-Tzer Gau - gau@ William Horvath - suhorvath@ Paolo Ventura - paoloven@ Chung-Tsen Hsueh - CHsueh@ Wayne Carlsen - carlsen@ Corresponding author Published 18 December 2008 Received 7 November 2008 Journal of Hematology Oncology 2008 1 26 doi 1756-8722-1-26 Accepted 18 December 2008 This article is available from http content 1 1 26 2008 Acharya et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Concurrent hemolysis in patients with vitamin B12 deficiency is a well-recognized phenomenon and has been attributed to intramedullary destruction of erythrocytes ineffective erythropoiesis . Recent studies revealed that homocysteine increased the risk of hemolysis in vitamin B12 deficiency in vitro and there is a high frequency 30 of vitamin B12 deficiency in asymptomatic patients with homozygous methylene tetrahydrofolate .
