Giảo cổ lam (GCL) là nguồn dược liệu dồi dào ở Việt Nam. Các gypenosid trong GCL thuộc nhóm saponin triterpenoid khung dammaran đã được chứng minh có tác dụng giữ ẩm, chống oxy hóa, chống già hoá da. Bài viết trình bày nghiên cứu bào chế và ứng dụng hệ nano tự nhũ hóa cao khô Giảo cổ lam trong mỹ phẩm chăm sóc da. | VNU Journal of Science Medical and Pharmaceutical Sciences Vol. 39 No. 1 2023 20-29 Original Article Research on the Preparation of Self-nano-emulsifying Drug Delivery System Containing Gynostemma pentaphyllum Dry Extract for Application in Skin Care Cosmetics Vu Thi Thu Giang Pham Thuy Hanh Nguyen Van Lam Hanoi University of Pharmacy 13-15 Le Thanh Tong Hoan Kiem Hanoi Vietnam Received 12 February 2023 Revised 24 February 2023 Accepted 10 March 2023 Abstract Gynostemma pentaphyllum Thunb. Makino is a rich source of the herb in Vietnam. The gypenosides in this herb are triterpenoid saponins that have been shown to have moisturizing antioxidant and anti-aging effects on the skin. However gypenosides are hydrophilic and have a large molecular weight with a bulk molecular structure which prevents them from penetrating and absorbing into the skin. To apply the natural active ingredients from herbs into skin care cosmetics this research developed self-nano-emulsifying drug delivery systems SNEDDS containing Gynostemma pentaphyllum dry extract and applied them to emulgel skin care cosmetics. Prepared SNEDDS could self-emulsify in the water to form nanoemulsions with dispersed droplet sizes less than 20 nm with PDI lt . The proportion of saponin entrapped in the oil droplets of nano emulsification was more than 90 . When combined with emulgel excipients the obtained cosmetic products had nano-sized dispersed droplets less than 200 nm with uniform droplet size distribution which are promising for application when further research is carried out. Keywords Self-nano-emulsifying Drug Delivery System SNEDDS Gymnostemma pentaphyllum dry extract cosmetic emulgel nano-emulsion. _ Corresponding author. E-mail address giangvtt@ https 2588-1132 20 V. T. T. Giang et al. VNU Journal of Science Medical and Pharmaceutical Sciences Vol. 39 No. 1 2023 20-29 21 Nghiên cứu bào chế và ứng dụng hệ nano tự nhũ hóa cao khô Giảo cổ lam trong mỹ phẩm .
